Part1. What is Echinacea Angustifolia Extract?
Echinacea Angustifolia extract is a product extracted from Echinacea Purpurea, E. agustifolia or E. pallida as a raw material, and is a light yellow or yellow-green fine powder. The main components are phenolic compounds, and also contain a variety of alkylamines, flavonoids, polysaccharides and a small amount of volatile oil. It has antibacterial, antiviral, and immune-boosting functions. Can be used as immunomodulator and immunostimulator. It has anti-viral, anti-fungal, anti-tumor and anti-inflammatory effects. It can stimulate the immune response, strengthen the immune system, prevent influenza, shorten the period of colds and colds, assist in the treatment of arthritis or skin diseases, promote wound healing, relieve toothache and burn pain, fight against bacterial and viral infections, and assist in the treatment of cancer.
Part2. Pharmacological effects
1. Immunostimulatory effect of inulin:
It plays a role by increasing the number of granulocytes and white blood cells, and can improve the chemotaxis of monocytes and neutral viruses to produce bacteriolysis. Polysaccharides: T lymphocytes and hydrocarbon receptors on the surface of macrophages produce immunostimulatory effects, which can enhance the phagocytic ability of macrophages, and stimulate macrophages to increase the number of tumor necrosis factors, interferons, and leukocyte mediators. destroy tumor cells. Alkylamines and caffeic acid derivatives: Lipophilic alkylamines can increase the phagocytic ability of macrophages.
Echinacea: Improve the activity of non-specific T cells, produce interferon, promote the secretion of lymphocytes, reduce T-helper cells, and reduce the ratio of T-helper cells to inhibitory factors.
2. Tissue renewal and anti-infection effect
Inhibition of hyaluronidase (hyaluronidase) can stimulate the growth of fibroblasts and the synthesis of glucosaminidase, produce corticosterone-like effects, and promote the secretion of adrenal cortex hormones. Polysaccharides have anti-infective effects.
3. Antibacterial effect
Echinacea and caffeic acid derivatives have weak antibacterial activity. The n-hexane extract inhibited the growth of yeast strains of Saccharomyc escerevisiae, Candidashehata, C.kefyr, C.albicans, C.steatulytica and C.tropicalis to varying degrees under near-UV light, without inhibition under light (general antifungal effect) To a lesser extent. Among the isolated compounds, trideca-1-ene-3, 5, 7, 9, 10-pentayne had obvious phototoxicity, while undeca-2E, 4Z-di-ene-8, 10-diynoic acid isobutylamine and decade -2E, 4E, 8Z, 10E/Z-tetraenoic acid isobutylamine has only weak phototoxicity. The phototoxic effects of Echinacea are mainly attributed to the abundance of hydrocarbons and ketoalkynes in the roots.
4. Antiviral effect
Can inhibit influenza, herpes and blistering viruses, antiviral activity is attributed to the inhibition of hyaluronidase, which can block the virus receptors on the cell surface.
5. Toxic and side effects
Excessive use may cause low-grade fever and dermatitis in sensitive patients.
Part3. Clinical efficacy
Echinacea and its extracts are used for common infections or wounds, colds or flu, candidiasis, candidiasis, staph infections, urinary tract infections, pelvic inflammation (P.I.D), tonsil inflammation, upper respiratory tract infection, wound inflammation, toothache Or mouth infections, mosquito, animal or snake bites, blood or food poisoning, boils, abscesses, eczema.
Part4. Application
As an immunomodulator and immune booster, Echinacea has been approved as an over-the-counter drug in Germany. Its preparation was listed in the 2000 most commonly used prescriptions as early as 1989, ranking 131. At present, there are more than 300 kinds of Echinacea unilateral preparations and compound preparations in Germany, the most common ones are oral leaching preparations, injections, suppositories, ointments, etc., the most famous of which is the immunomodulator produced by Schaper & Brummer Pharmaceuticals in Germany. Polycom (EsberitorN, containing echinacea root, arborvitae leaf, and indigo root), immune enhancer Espa-Imun drops produced by Esparma in Germany, and antibacterial and antiviral Echinacin preparations for respiratory tract and urinary tract Infected ImmunopertEchinacea's drops, tablets, UralytCapsules, etc., are used to prevent urinary solids and relieve renal solid colic.
Echinacea products are the best-selling over-the-counter herbal products in the North American market. The United States, Canada and other countries use EA roots to treat mouth and throat sores. From 1995 to 1998, Echinacea purpurea ranked first in the US herbal medicine market sales list, accounting for more than 10% of the food supplement market.
